Tabasco sauce is a brand of hot sauce made from tabasco peppers (Capsicum frutescens var. tabasco), vinegar, and salt, and aged in white oak barrels for three years.

It has a hot, spicy flavor and is popular in many parts of the world.

Tabasco is trademarked as the brand name for the variety of tabasco sauce marketed by the McIlhenny Company of Avery Island, Louisiana.

Often, the word "tabasco" is rendered in lowercase when referring to the botanical variety, but in uppercase, "Tabasco," when referring to the actual trademarked brand name. While there are many other kinds of "hot pepper sauce" on the market, most of them are similar to Tabasco, and Tabasco is by far the most recognized.

Although it is produced in the United States, it acquired its name from the state of Tabasco in Mexico.